Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis
نویسندگان
چکیده
منابع مشابه
The swinging lever-arm hypothesis of muscle contraction
The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and biochemists for many years. The common view of the mechanism is embodied in the 'cross-bridge hypothesis', in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated muscle is brought about by the 'cross-bridges', parts of the myosin molecules which protrude from the...
متن کاملKinematics of the lever arm swing in myosin VI.
Myosin VI (MVI) is the only known member of the myosin superfamily that, upon dimerization, walks processively toward the pointed end of the actin filament. The leading head of the dimer directs the trailing head forward with a power stroke, a conformational change of the motor domain exaggerated by the lever arm. Using a unique coarse-grained model for the power stroke of a single MVI, we prov...
متن کاملMyosin VI lever arm rotation: fixed or variable?
Two recent articles addressed the power-stroke of myosin VI molecules during stepping. Although both groups measured the angles of fluorescent probes attached on the myosin VI molecule lever arm using polarized fluorescence techniques, they differ about whether the myosin VI lever arm rotation is fixed or variable. Here we discuss the causes of the discrepancy between the two studies and the im...
متن کاملEssential "ankle" in the myosin lever arm.
C ellular motors are fascinating machines that function by undergoing successive conformational changes that require joints in their structure. Where these are located is particularly critical for molecular motors that produce force with relatively rigid lever arms, such as myosins (1). A long-standing paradox in myosin function may finally be understood from structural insights provided by Coh...
متن کاملLever arm extension of myosin VI is unnecessary for the adjacent binding state
Myosin VI is a processive myosin that has a unique stepping motion, which includes three kinds of steps: a large forward step, a small forward step and a backward step. Recently, we proposed the parallel lever arms model to explain the adjacent binding state, which is necessary for the unique motion. In this model, both lever arms are directed the same direction. However, experimental evidence ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2833